The shared responsibility model
AWS is responsible for security OF the cloud: physical facilities, hardware, and the underlying network and virtualization layer. You're responsible for security IN the cloud: your data, IAM configuration, guest OS patching (for EC2), network traffic protection, and how you configure every service you use. The split shifts with the service model — for a managed service like RDS, AWS also patches the database engine itself, narrowing what you're responsible for compared to running a database yourself on EC2.